Unlike the previous MTG crossovers, which were set in different worlds, Strixhaven is designed to be dropped into any D&D campaign. The book features an adventure that can be played from levels 1-10 or broken up into four standalone games, each representing a year spent at the college. Each of those can be completed in two or three sessions.
A bestiary contains 40 new creatures, plus NPCs including professors and the dragons that founded each college. Players will also find rules for Owlin, a new avian race that was previously tested in Unearthed Arcana, plus feats, spells, and items such as magical textbooks to further immerse them in the setting.